Scott Swanson, Ph.D.
University of Michigan
Magnetization transfer MRI: principles, practice, and new potential (more ...)
Magnetization transfer MRI: principles, practice, and new potential (hide ...)
Magnetization transfer (MT) MRI indirectly images the semisolid components of tissues (large proteins, polysaccharides, and phospholipids) by means of the easily detected water signal. Recent work has identified that a variant of MT, termed inhomogeneous MT (ihMT), creates MR images that are highly specific to the lipids in myelin. This talk will outline the biophysical foundations of MT and ihMT, present methods to measure lipid fluidity and lipid order in model myelin membranes, and discuss future applications to white matter diseases such as multiple sclerosis.