My research involves the development and application of computational methods (classification and estimation) in imaging with different modalities, such as PET, SPECT and MRI. In particular, I am interested in vivo imaging of Alzheimer's disease in both human and transgenic mouse models of AD.
My current research is focused on developing novel image analysis methods for positron emission tomography (PET) to monitor abnormal changes in functional and pathological hallmarks of Alzheimer's disease (AD). It is know that abnormal amyloid accumulation and neurodegeneration occur years or decades before the onset of clinical symptoms. I am particularly interested in developing PET methods for preclinical AD where individuals are classified as cognitively normal by having none or very little cognitive alterations but do not meet the criteria for mild cognitive impairment (MCI). A major challenge of current preclinical AD research, is to construct models of disease progression that estimate the biomarker dynamics directly from real-world experimental data. We are developing image analysis techniques to determine time trajectories for Aβ-PET and FDG-PET and to predict the subject's risk for developing decline in cognition and clinical conversion to MCI.
Shokouhi S, Wilson DW, Metzler SD, Peterson TE, Evaluation of image reconstruction for mouse brain imaging with synthetic collimation from highly multiplexed SiliSPECT projections. Phys. Med. Biol 2010; 55:5151-5168. (PMC3808864)
Shokouhi S, Claassen D, Kang H, Ding Z, Rogers B, Mishra A, Riddle WR. Longitudinal progression of cognitive decline correlates with changes in the spatial pattern of brain FDG-PET. J Nucl Med 2013;54:1564-9 (PMC4134885)
Shokouhi S, Claassen D, Riddle WR. Imaging Brain Metabolism and Pathology in Alzheimer?s Disease with Positron Emission Tomography. J Alzheimer?s Dis Parkinsonism 2014; 4:2
Johnson LC, Shokouhi S, Peterson TE. Reducing Multiplexing Artifacts in Small-Animal Multi-Pinhole SPECT with a Simulated Stacked Silicon-Germanium System, IEEE TMI, July 2014 In Press
Shokouhi S, Rogers BP, Kang H, Ding Z, Claassen DO, Mckay JW, Riddle WR. Modeling clustered activity increase in amyloid-beta positron emission tomographic images with statistical descriptors. Clin Interv Aging. 2015 Apr 20;10:759-70.