I am interested in the design and synthesis of small molecules with the goal of developing them into PET tracers as imaging agents for cancer.
Cancer cells have higher energy requirements than normal cells and therefore have increased amino acid transport and retention. The neutral amino acid transporter, ASCT2, has been found in elevated levels in oncology and may correlate with disease progression and prognosis. Probes capable of determining ASCT2 levels in vivo may have potential as cancer imaging biomarkers. My current research is focused on the development of novel ligands for the amino acid transporter ASCT2 as well as assay development allowing for the determination of potency, affinity, and selectivity of these ligands.
Schulte, M.L.; Turlington, M.L.; Phatak, S.S.; Harp, J.M.; Stauffer, S.R.; Lindsley, C.W. 'Total Synthesis of Stemaphylline N-Oxide and Related C9a-Epimeric Analogues.' Chem. Eur. J., 2013, 19(36), 11847-11852.
Senter, T.J.; Schulte, M.L.; Konkol, L.C.; Wadzinski, T.E.; Lindsley, C.W. 'A general, enantioselective synthesis of 1-azabicyclo[m.n.0]alkane ring systems' Tet. Lett., 2013, 54, 1645-1648
Young, S.E.; Duvernay, M.T.; Schulte, M.L.; Lindsley, C.W.; Hamm, H.E. 'Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets.' PLoS ONE, 2013, 8(6), e65528.
Xiang, Z.; Thompson, A.D.; Brogan, J.T.; Schulte, M.L.; Melancon, B.J.; Mi, D.; Lewis, L.M. Zou, B.; Yang, L.; Morrison, R.; Santomango, T.; Byers, F.; Brewer, K.; Aldrich, J.S.; Yu, H.; Dawson, E.S.; Li, M.; McManus, O.; Jones, C.K.; Daniels, J.S.; Hopkins, C.R.; Xie, X.S.; Conn, P.J.; Weaver, C.D.; Lindsley, C.W. 'The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.' ACS Chemical Neuroscience, 2011, 2(12), 730-742.
Schulte, M.L.; Lindsley, C.W. 'Highly diastereoselective and general synthesis of primary ë_-fluoroamines.' Org. Lett., 2011, 13(20), 5684-5687.