I am interested in the development of novel MR imaging methods to better characterize cerebrovascular disease.
Sickle cell anemia (SCA) is a genetic disorder with a high prevalence of cerebrovascular disease. My current project involves the use of MRI to characterize metabolism and perfusion for the purpose of developing imaging strategies for stroke risk stratification in patients affected by SCA.
Juttukonda MR, Mersereau BG, Chen Y, Su Y, Rubin B, Benzinger TLS, Lalush DS, and An H. 'MR-based attenuation correction for PET/MRI neurological studies with continuous-valued attenuation coefficients for bone through a conversion from R2* to CT-Hounsfield units.' Neuroimage. 2015 Mar 14; doi: 10.1016/j.neuroimage.2015.03.009.
Chen Y, Juttukonda M, Su Y, Rubin BG, Lee YZ, Lin W, Shen D, Lalush DS, and An H. 'Probabilistic Air Segmentation and Sparse Regression Estimated Pseudo CT for PET/MR Attenuation Correction.' Radiology. 2014 Dec 17; doi: 10.1148/radiol.14140810
Dortch RD, Harkins KR, Juttukonda MR, Gore JC, and Does MD. 'Characterizing the inter-compartmental water exchange in myelinated tissue using relaxation exchange spectroscopy.' Magnetic Resonance in Medicine. 2013; 70: 1450-1459. doi: 10.1002/mrm.24571