My work includes assisting with the design and implementation of advanced imaging techniques and data analysis protocols for clinical trials being performed at the Vanderbilt Ingram Cancer Clinic (VICC). Current projects include MR and PET studies of treatment assessment in breast cancer and an MR study of treatment assessment in pancreatic cancer.
I am currently working on the development and improvement of quantitative MRI methods (at 3T) for use in treatment assessment in breast cancer. These methods include diffusion-weighted image (DWI), magnetization transfer (MT) imaging, and chemical exchange saturation transfer (CEST) imaging.
Arlinghaus, L. R., Li, X., Rahman, A. R., Welch, E. B., Xu, L., Gore, J. C., Yankeelov, T. E. On the relationship between the apparent diffusion coefficient and extravascular extracellular volume fraction in human breast cancer. Magnetic Resonance Imaging 2011, 29 (5), 630-8.
Arlinghaus, L. R., Welch, E. B., Chakravarthy, A. B., Xu, L., Farley, J. S., Abramson, V. G., Grau, A. M., Kelley, M. C., Mayer, I. A., Means-Powell, J. A., Meszoely, I. M., Gore, J. C., Yankeelov, T. E. Motion correction in diffusion-weighted MRI of the breast at 3T. Journal of Magnetic Resonance Imaging 2011, 33 (5), 1063-70.
Yankeelov, T. E., Arlinghaus, L. R., Li, X., Gore, J. C. The role of magnetic resonance imaging biomarkers in clinical trials of treatment response in cancer. Seminars in Oncology 2011, 38 (1), 16-25.
Arlinghaus, L. R., Li, X., Levy, M., Smith, D., Welch, E. B., Gore, J. C., Yankeelov, T. E. Current and future trends in magnetic resonance imaging assessments of the response of breast tumors to neoadjuvant chemotherapy [published online ahead of print September 29 2010]. Journal of Oncology 2010.