Daniel Perrien, Ph.D.Assistant Professor
Division of Clinical Pharmacology in the Department of Medicine
In my role at the VUIIS, I focus on the development of techniques to assess skeletal phenotypes and biological processes. While microCT based analysis has become the major workhorse for phenotyping of mineralized and soft skeletal tissues, I collaborate with other VUIIS faculty to apply optical, nuclear, and MR based approaches to study skeletal signaling and metabolism in vivo.
Bi X, Sterling JA, Merkel A, Perrien DS, Nyman J, and Mahadevan-Jansen A. Prostate Cancer Metastases Alter Bone Mineral and Matrix Composition Independent of Effects on Bone Architecture in Mice " A Quantitative Study Using microCT and Raman Spectroscopy. BONE. E-pub 2013 July 15. http://dx.doi.org/10.1016/j.bone.2013.07.006,
Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A Secreted Bacterial Protease Tailors the Staphylococcus aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis. Cell Host Microbe. 2013 Jun 12;13(6):759-72. doi: 10.1016/j.chom.2013.05.003. PMID:23768499
Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, and West J. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 Mar;302(5):L474-84.Dec 16, 2011. [Epub ahead of print] PMID: 22180660
Sparks EE, Perrien DS, Huppert KA, Peterson TE, and Huppert SS. Notch signaling is required for the maintenance of functional IHBDs in mouse liver, but not the identity of ductal cells. Disease Models and Mechanims. Published online Jan 31, 2011. PMID: 21282722
Perrien DS, Akel NS, Swain FL, Carver AA, Edwards PK, Skinner RA, Montague DC, Suva LJ, and Gaddy D. Inhibin A is an endocrine stimulator of bone mass and strength. Endocrinology. 148(4):1654-65, April 2007. PMID: 17194739